Review



selective nmda receptor antagonist  (Tocris)


Bioz Verified Symbol Tocris is a verified supplier
Bioz Manufacturer Symbol Tocris manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 96
      Buy from Supplier

    Structured Review

    Tocris selective nmda receptor antagonist
    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in <t>the</t> <t>AMPA/NMDA</t> ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.
    Selective Nmda Receptor Antagonist, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 2070 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/selective nmda receptor antagonist/product/Tocris
    Average 96 stars, based on 2070 article reviews
    selective nmda receptor antagonist - by Bioz Stars, 2026-06
    96/100 stars

    Images

    1) Product Images from "Compound- and sex-specific medial prefrontal cortex rewiring after prenatal THC and CBD exposure"

    Article Title: Compound- and sex-specific medial prefrontal cortex rewiring after prenatal THC and CBD exposure

    Journal: bioRxiv

    doi: 10.64898/2026.02.13.705680

    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in the AMPA/NMDA ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.
    Figure Legend Snippet: (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in the AMPA/NMDA ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.

    Techniques Used: MANN-WHITNEY, Comparison



    Similar Products

    selective nmda receptor antagonist  (Tocris)
    96
    Tocris selective nmda receptor antagonist
    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in <t>the</t> <t>AMPA/NMDA</t> ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.
    Selective Nmda Receptor Antagonist, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/selective nmda receptor antagonist/product/Tocris
    Average 96 stars, based on 1 article reviews
    selective nmda receptor antagonist - by Bioz Stars, 2026-06
    96/100 stars
    		  Buy from Supplier
    nmda receptor selective antagonist ly235959  (Tocris)
    96
    Tocris nmda receptor selective antagonist ly235959
    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in <t>the</t> <t>AMPA/NMDA</t> ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.
    Nmda Receptor Selective Antagonist Ly235959, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nmda receptor selective antagonist ly235959/product/Tocris
    Average 96 stars, based on 1 article reviews
    nmda receptor selective antagonist ly235959 - by Bioz Stars, 2026-06
    96/100 stars
    		  Buy from Supplier
    2 amino 5 phosphonopentanoic acid d ap5 a potent and selective antagonist of nmda receptors tocris bioscience bristol uk  (Tocris)
    97
    Tocris 2 amino 5 phosphonopentanoic acid d ap5 a potent and selective antagonist of nmda receptors tocris bioscience bristol uk
    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in <t>the</t> <t>AMPA/NMDA</t> ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.
    2 Amino 5 Phosphonopentanoic Acid D Ap5 A Potent And Selective Antagonist Of Nmda Receptors Tocris Bioscience Bristol Uk, supplied by Tocris, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/2 amino 5 phosphonopentanoic acid d ap5 a potent and selective antagonist of nmda receptors tocris bioscience bristol uk/product/Tocris
    Average 97 stars, based on 1 article reviews
    2 amino 5 phosphonopentanoic acid d ap5 a potent and selective antagonist of nmda receptors tocris bioscience bristol uk - by Bioz Stars, 2026-06
    97/100 stars
    		  Buy from Supplier
    nmda receptor selective and non-competitive antagonist (+)-mk-801 (dizocilpine)  (Tocris)
    90
    Tocris nmda receptor selective and non-competitive antagonist (+)-mk-801 (dizocilpine)
    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in <t>the</t> <t>AMPA/NMDA</t> ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.
    Nmda Receptor Selective And Non Competitive Antagonist (+) Mk 801 (Dizocilpine), supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nmda receptor selective and non-competitive antagonist (+)-mk-801 (dizocilpine)/product/Tocris
    Average 90 stars, based on 1 article reviews
    nmda receptor selective and non-competitive antagonist (+)-mk-801 (dizocilpine) - by Bioz Stars, 2026-06
    90/100 stars
    		  Buy from Supplier
    selective nmda receptor glun2b subunit antagonist cp-101,606  (Axon Medchem LLC)
    90
    Axon Medchem LLC selective nmda receptor glun2b subunit antagonist cp-101,606
    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in <t>the</t> <t>AMPA/NMDA</t> ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.
    Selective Nmda Receptor Glun2b Subunit Antagonist Cp 101,606, supplied by Axon Medchem LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/selective nmda receptor glun2b subunit antagonist cp-101,606/product/Axon Medchem LLC
    Average 90 stars, based on 1 article reviews
    selective nmda receptor glun2b subunit antagonist cp-101,606 - by Bioz Stars, 2026-06
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in the AMPA/NMDA ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.

    Journal: bioRxiv

    Article Title: Compound- and sex-specific medial prefrontal cortex rewiring after prenatal THC and CBD exposure

    doi: 10.64898/2026.02.13.705680

    Figure Lengend Snippet: (A, B) Averaged fEPSP amplitudes plotted as a function of stimulus intensity. Synaptic strength remains stable across treatments, indicating that baseline recruitment does not account for the observed plasticity differences. (C) CBD-exposed males show a significant increase in the AMPA/NMDA ratio in layer V pyramidal neurons of the mPFC. (D) Representative traces of NMDA-EPSCs (red) evoked at +30 mV in the presence of 50 µM NBQX, and AMPA-EPSCs (blue) obtained by digital subtraction of the NMDA component from the dual-component current at +30 mV. (E, F) CBD alters the kinetics of evoked NMDA currents. Male CBD-exposed offspring exhibit slower rise times, whereas CBD-exposed females display faster decay kinetics. (A, B) Each point represents the group mean at the corresponding stimulus intensity; data are shown as mean ± SEM in XY plots and analyzed using a multiple-measures Mann–Whitney test. (C, E, F) Each point represents a single neuron; data are presented as violin plots (median and 25th–75th percentiles) and analyzed using two-way ANOVA followed by Šídák’s multiple-comparison test. Only statistically significant differences (p < 0.05) are indicated.

    Article Snippet: GABA-sIPSCs were recorded at − 70 mV in presence of 20 μM CNQX (6-Cyano-7-nitroquinoxaline-2,3-dione disodium, an AMPA receptor antagonist, Tocris) and L-APV 50 μM (DL-2-Amino-5-phosphonopentanoic acid, a selective NMDA receptor antagonist, Tocris).

    Techniques: MANN-WHITNEY, Comparison